BRAF V600E genetic mutation analysis in patients had been diagnosed of unknown malignancy potential thyroid tumors and papillary thyroid microcarcinoma
نویسندگان
چکیده
منابع مشابه
Papillary microcarcinoma in comparison with larger papillary thyroid carcinoma in BRAF(V600E) mutation, clinicopathological features, and immunohistochemical findings.
BACKGROUND Papillary thyroid microcarcinoma (PMC; <or=1 cm) is thought to take a benign course during the lifetime. However, recent studies showed high recurrence rates for PMC. METHODS We analyzed the clinicopathological features, long-term prognosis, and some molecular characteristics including BRAF(V600E) mutation by retrospectively reviewing the records of 1150 patients with papillary thy...
متن کاملAssociation between the BRAF V600E mutation and ultrasound features of the thyroid in thyroid papillary carcinoma
The aim of the present study was to investigate the association between the BRAF V600E mutation and ultrasound features of the thyroid in papillary thyroid carcinoma (PTC). Fresh thyroid carcinoma tissue and paracarcinoma tissue were obtained from 34 patients undergoing surgery for PTC. The BRAF V600E mutation was detected by PCR amplification and direct DNA sequencing. The thyroid ultrasound r...
متن کاملThe BRAF(V600E) mutation in papillary thyroid microcarcinoma: does the mutation have an impact on clinical outcome?
CONTEXT An activating mutation in the gene BRAF has been correlated with poorer prognosis and more aggressive clinical course in papillary thyroid carcinoma (PTC). We therefore hypothesized that the good prognosis, high 5-year disease-free rate and high survival rate of patients with less aggressive papillary thyroid microcarcinoma (pT1aNo-x) would be associated with a lower incidence of the BR...
متن کاملPotential relationship between Hashimoto's thyroiditis and BRAF(V600E) mutation status in papillary thyroid cancer.
BACKGROUND The purpose of this study was to evaluate the potential relationship between Hashimoto's thyroiditis and BRAF(V600E) mutation status in patients with papillary thyroid carcinoma (PTC). METHODS A total of 619 patients with PTC who underwent total thyroidectomy with lymph node dissection were enrolled in this study. Univariable and multivariate analyses were used. RESULTS Hashimoto...
متن کاملPreoperative BRAF Mutation is Predictive of Occult Contralateral Carcinoma in Patients with Unilateral Papillary Thyroid Microcarcinoma
Thyroid cancer is the most common endocrine malignancy, accounting for 1% of all malignant tumors in the USA (Sherman, 2003) and 5.9% in one district of Wenzhou (a coastal city in Southeast China, with a incidence of 21/100,000) (Zheng and Zhang, 2007). The incidence of papillary thyroid carcinoma, which is the most common histologic type of thyroid malignancy, is increasing worldwide (Davies a...
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ژورنال
عنوان ژورنال: Endocrine Abstracts
سال: 2014
ISSN: 1479-6848
DOI: 10.1530/endoabs.35.p1150